Article

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways

2024-08-30

Abstract excerpt

Genome-wide association studies have identified thousands of common variants associated with an increased risk of neurodegenerative disorders. However, the noncoding localization of these variants has made the assignment of target genes for brain cell types challenging. Genomic approaches that infer chromosomal 3D architecture can link noncoding risk variants and distal gene regulatory elements such as enhancers t...

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Literature Corpus work: 10bb90eb-2ebf-51e1-bc40-a5e3fba32140
DOI: 10.1101/2024.08.29.610255

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