Article

Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia

2024-05-24

Abstract excerpt

<title>Abstract</title> <p>Despite genome-wide association studies of late-onset Alzheimer’s disease (LOAD) having identified many genetic risk loci 1-6, the underlying disease mechanisms remain largely unknown. Determining causal disease variants and their LOAD-relevant cellular phenotypes has been a challenge. Leveraging our approach for identifying functional GWAS risk variants showing allele-specific open chr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78507ef7-3fc0-56e4-9679-fb0687f3be88
DOI: 10.21203/rs.3.rs-4407146/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microgliaDOI 10.21203/rs.3.rs-4407146/v1Read

PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.Semantic proximity Read

An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.Semantic proximity Read

MEF2C controls lysosomal and lipid clearance programs linked to Alzheimer’s disease risk in macrophagesSemantic proximity Read

An integrated genome and phenome-wide association study approach to understanding Alzheimer’s disease predispositionSemantic proximity Read

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.Semantic proximity Read

Alzheimer’s disease protective allele of <i>Clusterin</i> modulates neuronal excitability through lipid-droplet-mediated neuron-glia communicationSemantic proximity Read

PLCG2 as a Risk Factor for Alzheimer's DiseaseSemantic proximity Read

PLCG2 as a Risk Factor for Alzheimer's Disease.Semantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathwaysSemantic proximity Read

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microgliaSemantic proximity Read

Variant-to-function mapping of late-onset Alzheimer’s disease GWAS signals in human microglial cell models implicates <i>RTFDC1</i> at the <i>CASS4</i> locusSemantic proximity Read