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The Role of PICALM in Alzheimer's Disease.

Molecular neurobiology - 1 Aug 2015

Xu Wei, Tan Lan, Yu Jin-Tai

Abstract excerpt

Alzheimer's disease (AD) is a highly heritable disease (with heritability up to 76%) with a complex genetic profile of susceptibility, among which large genome-wide association studies (GWASs) pointed to the phosphatidylinositol-binding clathrin assembly protein (PICALM) gene as a susceptibility locus for late-onset Alzheimer's disease (LOAD) incidence. Here, we summarize the known functions of PICALM and discuss...

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Alzheimer Disease
Amyloid beta-Peptides
PICALM gene
Genetic Predisposition to Disease
Models, Biological
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monomeric Clathrin Assembly Proteins

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PMID: 25186232
DOI: 10.1007/s12035-014-8878-3

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PICALM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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