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Article

The Alzheimer's disease-associated complement receptor 1 variant confers risk by impacting glial phagocytosis.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025

Daskoulidou Nikoleta, Shaw Bethany, Zelek Wioleta Milena, Morgan Bryan Paul

Abstract excerpt

INTRODUCTION: Genome-wide association studies have implicated complement in Alzheimer's disease (AD). The CR1*2 variant of complement receptor 1 (CR1; CD35), confers increased AD risk. We confirmed CR1 expression on glial cells; however, how CR1 variants influence AD risk remains unclear. METHODS: Induced pluripotent stem cell-derived microglia and astrocytes were generated from donors homozygous for the common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40631443
DOI: 10.1002/alz.70458
PMCID: PMC12238831

Genes

CR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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