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Complement receptor 1 is expressed on brain cells and in the human brain

24 Feb 2023

Abstract excerpt

Genome wide association studies (GWAS) have highlighted the importance of the complement cascade in pathogenesis of Alzheimer's disease (AD). Complement receptor 1 (CR1; CD35) is among the top GWAS hits. The long variant of CR1 is associated with increased risk for AD; however, roles of CR1 in brain health and disease are poorly understood. A critical confounder is that brain expression of CR1 is controversial;...

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PMID: 36825534
DOI: 10.1002/glia.24355

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