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Article

Complement and microglia mediate early synapse loss in Alzheimer mouse models

31 Mar 2016

Abstract excerpt

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade, is increased and associated with synapses before overt plaque...

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PMID: 27033548
DOI: 10.1126/science.aad8373

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