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Microglia, Alzheimer's Disease, and Complement

1 Jan 2012

Abstract excerpt

Microglia, the immune cell of the brain, are implicated in cascades leading to neuronal loss and cognitive decline in Alzheimer's disease (AD). Recent genome-wide association studies have indicated a number of risk factors for the development of late-onset AD. Two of these risk factors are an altered immune response and polymorphisms in complement receptor 1. In view of these findings, we discuss how complement...

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PMID: 22957298
DOI: 10.1155/2012/983640

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