Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.

doi:10.1016/j.neurobiolaging.2012.07.001

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Article

Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.

Neurobiology of aging - 1 Dec 2012

Hazrati Lili-Naz, Van Cauwenberghe Caroline, Brooks Patricia L, Brouwers Nathalie, Ghani Mahdi, Sato Christine, Cruts Marc, Sleegers Kristel, St George-Hyslop Peter, Van Broeckhoven Christine, Rogaeva Ekaterina

Abstract excerpt

CR1 is a novel Alzheimer's disease (AD) gene identified by genome-wide association studies (GWAS). Recently, we showed that AD risk could be explained by an 18-kilobase insertion responsible for the complement component (3b/4b) receptor 1 (CR1)-S isoform. We investigated the relevance of the CR1 isoforms to AD in a Canadian dataset. Also, we genotyped rs4844610 tagging the GWAS-significant CR1 single nucleotide...

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PMID: 22819390
DOI: 10.1016/j.neurobiolaging.2012.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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