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Article

Genetic Insights into the Impact of Complement in Alzheimer's Disease.

Genes - 15 Dec 2021

Torvell Megan, Carpanini Sarah M, Daskoulidou Nikoleta, Byrne Robert A J, Sims Rebecca, Morgan B Paul

Abstract excerpt

The presence of complement activation products at sites of pathology in post-mortem Alzheimer's disease (AD) brains is well known. Recent evidence from genome-wide association studies (GWAS), combined with the demonstration that complement activation is pivotal in synapse loss in AD, strongly implicates complement in disease aetiology. Genetic variations in complement genes are widespread. While most variants...

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Identifiers

PMID: 34946939
DOI: 10.3390/genes12121990
PMCID: PMC8702080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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