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High complement levels in astrocyte‐derived exosomes of Alzheimer disease

6 Feb 2018

Abstract excerpt

OBJECTIVE: Astrocytes fulfill neuronal trophic roles normally, but are transformed in Alzheimer disease (AD) into A1-type reactive astrocytes that may destroy neurons through unknown mechanisms. METHODS: To investigate astrocyte inflammatory mechanisms, astrocyte-derived exosomes (ADEs) were isolated immunochemically from plasma samples of AD patients and matched controls for enzyme-linked immunosorbent assay...

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PMID: 29406582
DOI: 10.1002/ana.25172

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