Article

Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression

2022-04-02

Abstract excerpt

<h4>Background</h4> The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of phagocytes, and protects from pathogens. However, excessive downstream complement activation that leads to generation of C5a, and C5a engagement with its...

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Literature Corpus work: 80a5735c-0588-5804-860d-fab1e86b9ad7
DOI: 10.1101/2022.04.01.486759

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