Article
Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2018
Johansson Jenny U, Brubaker William D, Javitz Harold, Bergen Andrew W, Nishita Denise, Trigunaite Abhishek, Crane Andrés, Ceballos Justine, Mastroeni Diego, Tenner Andrea J, Sabbagh Marwan, Rogers Joseph
Abstract excerpt
INTRODUCTION: Genome-wide association studies consistently show that single nucleotide polymorphisms (SNPs) in the complement receptor 1 (CR1) gene modestly but significantly alter Alzheimer's disease (AD) risk. Follow-up research has assumed that CR1 is expressed in the human brain despite a paucity of evidence for its function there. Alternatively, erythrocytes contain >80% of the body's CR1, where, in...
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