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Article

Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

PloS one - 1 Jan 2016

Fonseca Maria I, Chu Shuhui, Pierce Aimee L, Brubaker William D, Hauhart Richard E, Mastroeni Diego, Clarke Elizabeth V, Rogers Joseph, Atkinson John P, Tenner Andrea J

Abstract excerpt

Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b receptor (CR1 or CD35) that are associated with late onset AD. Here, anti-CR1 antibodies (Abs) directed against different epitopes of the receptor, were used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26914463
DOI: 10.1371/journal.pone.0149792
PMCID: PMC4767815

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