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Article

Assessing the role of polygenic risk scores in cardiovascular risk prediction: a cross-sectional analysis from the Paracelsus 10 000 cohort.

European journal of preventive cardiology - 18 Feb 2026

Wernly Bernhard, Langthaler Patrick, Fixl Barbara, Kiesslich Tobias, Kedenko Ludmilla, Frey Vanessa, Trinka Eugen, Iglseder Bernhard, Flamm Maria, Aigner Elmar, Paulweber Bernhard

Abstract excerpt

AIMS: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality. SCORE2 may underestimate risk in those classified as low-to-moderate risk. Polygenic risk scores (PGSs) capture genetic predisposition to CVD and could enhance traditional models. This study examines whether integrating PGS with SCORE2 improves the prediction of significant subclinical coronary atherosclerosis, defined as...

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PMID: 40198844
DOI: 10.1093/eurjpc/zwaf206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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