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Advances and Applications of Polygenic Scores for Coronary Artery Disease.

Annual review of medicine - 27 Jan 2023

Patel Aniruddh P, Khera Amit V

Abstract excerpt

Polygenic scores quantify inherited risk by integrating information from many common sites of DNA variation into a single number. Rapid increases in the scale of genetic association studies and new statistical algorithms have enabled development of polygenic scores that meaningfully measure-as early as birth-risk of coronary artery disease. These newer-generation polygenic scores identify up to 8% of the...

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PMID: 36315649
DOI: 10.1146/annurev-med-042921-112629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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