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Article

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease.

European heart journal - 27 May 2024

Li Ling, Pang Shichao, Starnecker Fabian, Mueller-Myhsok Bertram, Schunkert Heribert

Abstract excerpt

BACKGROUND AND AIMS: It is not clear how a polygenic risk score (PRS) can be best combined with guideline-recommended tools for cardiovascular disease (CVD) risk prediction, e.g. SCORE2. METHODS: A PRS for coronary artery disease (CAD) was calculated in participants of UK Biobank (n = 432 981). Within each tenth of the PRS distribution, the odds ratios (ORs)-referred to as PRS-factor-for CVD (i.e. CAD or stroke)...

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Identifiers

PMID: 38551411
DOI: 10.1093/eurheartj/ehae048
PMCID: PMC11129792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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