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Combining European and U.S. risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

18 Jan 2023

Abstract excerpt

AIMS: A polygenic risk score (PRS) has the potential to improve individual atherosclerotic cardiovascular disease (ASCVD) risk assessment. To determine whether a PRS combined with two clinical risk scores, the Systematic COronary Risk Evaluation 2 (SCORE2) and the Pooled Cohort Equation (PCE) improves the prediction of ASCVD. METHODS AND RESULTS: Using a population-based European prospective cohort, with 6733...

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PMID: 36652418
DOI: 10.1093/eurjpc/zwad012

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