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Article

Reconstruction of diploid higher-order human 3D genome interactions from noisy Pore-C data using Dip3D.

Nature structural & molecular biology - 1 Jul 2025

Chen Ying, Lin Zhuo-Bin, Wang Shao-Kai, Wu Bo, Niu Longjian, Zhong Jia-Yong, Sun Yi-Meng, Zheng Zhenxian, Bai Xin, Liu Luo-Ran, Xie Wei, Chi Wei, Ye Tiantian, Luo Ruibang, Hou Chunhui, Luo Feng, Xiao Chuan-Le

Abstract excerpt

Differential high-order chromatin interactions between homologous chromosomes affect many biological processes. Traditional chromatin conformation capture genome analysis methods mainly identify two-way interactions and cannot provide comprehensive haplotype information, especially for low-heterozygosity organisms such as human. Here, we present a pipeline of methods to delineate diploid high-order chromatin...

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PMID: 40038455
DOI: 10.1038/s41594-025-01512-w

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