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Article

HaploC-tools reveal haplotype-specific chromosome conformation and chromatin states.

Nature communications - 25 Apr 2026

Liu Yuanlong, Franceschini Gian Marco, Zhang Yueyun, Oricchio Elisa, Ciriello Giovanni

Abstract excerpt

The sequences of homologous chromosomes differ in the presence of heterozygous single nucleotide polymorphisms (SNPs). Whether these differences translate into "heterozygous" chromatin three-dimensional structures is still largely unexplored. Here, we design HaploC-tools to optimize whole-chromosome phasing from high-throughput chromosome conformation capture (Hi-C) data and introduce tailored approaches to infer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42034903
DOI: 10.1038/s41467-026-72326-7
PMCID: PMC13323758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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