Article

High-throughput Pore-C reveals the single-allele topology polymorphism and cell type specificity of 3D genome folding

2022-06-15

Abstract excerpt

<title>Abstract</title> <p>Canonical three-dimensional (3D) genome structures represent the ensemble average of pairwise chromatin interactions but not the single-allele topologies in populations of cells. Recently developed Pore-C can capture multiway chromatin contacts that reflect regional topologies of single chromosomes. By carrying out high-throughput Pore-C, we reveal extensive but regionally restricted cl...

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Literature Corpus work: 59d0805b-c1e3-5d25-a056-a42291e9ff6c
DOI: 10.21203/rs.3.rs-1761017/v1

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