Article
High-throughput Pore-C reveals the single-allele topology and cell type-specificity of 3D genome folding.
Nature communications - 6 Mar 2023
Zhong Jia-Yong, Niu Longjian, Lin Zhuo-Bin, Bai Xin, Chen Ying, Luo Feng, Hou Chunhui, Xiao Chuan-Le
Abstract excerpt
Canonical three-dimensional (3D) genome structures represent the ensemble average of pairwise chromatin interactions but not the single-allele topologies in populations of cells. Recently developed Pore-C can capture multiway chromatin contacts that reflect regional topologies of single chromosomes. By carrying out high-throughput Pore-C, we reveal extensive but regionally restricted clusters of single-allele...
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