Article
ASHIC: hierarchical Bayesian modeling of diploid chromatin contacts and structures.
Nucleic acids research - 2 Dec 2020
Ye Tiantian, Ma Wenxiu
Abstract excerpt
The recently developed Hi-C technique has been widely applied to map genome-wide chromatin interactions. However, current methods for analyzing diploid Hi-C data cannot fully distinguish between homologous chromosomes. Consequently, the existing diploid Hi-C analyses are based on sparse and inaccurate allele-specific contact matrices, which might lead to incorrect modeling of diploid genome architecture. Here we...
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