Article

Integrating Single-Molecule Sequencing and Deep Learning to Predict Haplotype-Specific 3D Chromatin Organization in a Mendelian Condition

2025-03-02

Abstract excerpt

The three-dimensional (3D) architecture of the genome plays a crucial role in gene regulation and various human diseases. Short-read sequencing methods for measuring 3D genome organization are powerful, but they lack the ability to resolve individual human haplotypes or structurally complex regions. To address this, we present FiberFold, a deep learning model that combines convolutional neural networks and transfo...

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Literature Corpus work: a1d918f3-f854-5eac-beac-175de0e2a992
DOI: 10.1101/2025.02.26.640261

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