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Article

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset

7 Nov 2024

Abstract excerpt

Importance: Primary open-angle glaucoma (POAG) is a heritable disease. A polygenic risk score (PRS) threshold may be used to identify individuals at low risk of disease onset. Objective: To assess the utility of a POAG PRS to identify ocular hypertensive individuals at low risk of disease onset. Design, Setting, and Participants: This is a post hoc analysis of the Ocular Hypertension Treatment Study (OHTS), a...

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PMID: 39509108
DOI: 10.1001/jamaophthalmol.2024.4376

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