The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.

doi:10.1167/iovs.66.15.70

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Article

The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.

Investigative ophthalmology & visual science - 1 Dec 2025

Welzel Anna M, Brandl Caroline, Herold Janina M, Stingl Julia V, Hoffmann Esther M, Khawaja Anthony P, Zimmermann Martina E, Winkler Thomas, Stark Klaus J, Schmidtmann Irene, Wild Philipp S, Lackner Karl J, Lurz Philipp, Beutel Manfred E, Tüscher Oliver, Weinmann-Menke Julia, Pfeiffer Norbert, Heid Iris M, Schuster Alexander K

Abstract excerpt

Purpose: Genome-wide association studies have revealed many loci linked to glaucoma. The aim of this study was to explore the associations between a glaucoma polygenic risk score (GPRS) with glaucoma prevalence, intraocular pressure (IOP), and peripapillary retinal nerve fibre layer thickness (pRNFL) on a population-based level. Methods: Participants of the Gutenberg Health Study (aged 40-80 years) and the AugUR...

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Identifiers

PMID: 41533942
DOI: 10.1167/iovs.66.15.70
PMCID: PMC12758419

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