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Article

Polygenic risk scores for glaucoma: Impact on diagnosis and disease course.

Progress in retinal and eye research - 1 May 2026

Kolovos Antonia, Aung Tin, Khawaja Anthony P, Wiggs Janey L, Craig Jamie E

Abstract excerpt

Large-scale genomic studies have uncovered significant polygenic architecture of the adult-onset glaucomas, enabling the creation of polygenic risk scores (PRS). These scores show promise in improving early case detection and predicting disease trajectory, particularly when integrated with clinical parameters, signaling a new frontier for personalised glaucoma risk assessment. As accredited PRS tools enter...

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Identifiers

PMID: 41962831
DOI: 10.1016/j.preteyeres.2026.101469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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