Article

Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study

2023-08-16

Abstract excerpt

<h4>Objective or Purpose</h4> Primary open-angle glaucoma (POAG) is a highly heritable disease with 127 identified risk loci. Polygenic risks score (PRS) offers a measure of aggregate genetic burden. In this study, we assess whether PRS improves risk stratification in patients with ocular hypertension. <h4>Design</h4> A post-hoc analysis of the Ocular Hypertension Treatment Study (OHTS) data. <h4>Setting, Particip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd982fa4-31e6-5574-976b-3e59780ace1b
DOI: 10.1101/2023.08.15.23294141

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment StudyDOI 10.1101/2023.08.15.23294141Read

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease OnsetSemantic proximity Read

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestriesSemantic proximity Read

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.Semantic proximity Read

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at DiagnosisSemantic proximity Read

Polygenic risk scores for glaucoma: Impact on diagnosis and disease course.Semantic proximity Read

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across AncestriesSemantic proximity Read

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.Semantic proximity Read

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.Semantic proximity Read

Diversity in Polygenic Risk of Primary Open-Angle Glaucoma.Semantic proximity Read

Polygenic Risk Scores Driving Clinical Change in Glaucoma.Semantic proximity Read

Risk Stratification and Clinical Utility of Polygenic Risk Scores in OphthalmologySemantic proximity Read

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.Semantic proximity Read