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Article

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

JAMA ophthalmology - 1 Jan 2025

Chang-Wolf Jennifer M, Kinzy Tyler G, Driessen Sjoerd J, Cruz Lauren A, Iyengar Sudha K, Peachey Neal S, Aung Tin, Khor Chiea Chuen, Williams Susan E, Ramsay Michele, Olawoye Olusola, Ashaye Adeyinka, Klaver Caroline C W, Hauser Michael A, Thiadens Alberta A H J, Cooke Bailey Jessica N, Bonnemaijer Pieter W M

Abstract excerpt

Importance: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations. Objective: To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of African Descent (GIGA), Genetics of Glaucoma in Individuals of...

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PMID: 39541127
DOI: 10.1001/jamaophthalmol.2024.4784
PMCID: PMC11565374

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MVP

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