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Article

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.

JAMA ophthalmology - 1 Sept 2021

Siggs Owen M, Han Xikun, Qassim Ayub, Souzeau Emmanuelle, Kuruvilla Shilpa, Marshall Henry N, Mullany Sean, Mackey David A, Hewitt Alex W, Gharahkhani Puya, MacGregor Stuart, Craig Jamie E

Abstract excerpt

IMPORTANCE: Early diagnosis of open-angle glaucoma can lead to vision-saving treatment, and genetic variation is an increasingly powerful indicator in disease risk stratification. OBJECTIVE: To compare polygenic and monogenic variants in risk of glaucoma. DESIGN, SETTING, AND PARTICIPANTS: Clinical and genetic data were obtained for 2507 individuals from the Australian and New Zealand Registry of Advanced...

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Identifiers

PMID: 34264281
DOI: 10.1001/jamaophthalmol.2021.2440
PMCID: PMC8283675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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