Article

Genetic Risk Assessment of Degenerative Eye Disease (GRADE): Design of a prospective assessment of polygenic risk scores to predict diagnosis of glaucoma and age-related macular degeneration.

2023-06-08

Abstract excerpt

<h4>Background: </h4> Glaucoma and age-related macular degeneration (AMD) account for a substantial portion of global blindness. Both conditions are highly heritable, with recognised monogenic and polygenic inheritance patterns. Current screening guidelines lack decisive recommendations. Polygenic risk scores (PRS) allow for cost-effective broad population risk stratification for these conditions. The predictive p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c7b0a4a3-e24a-545e-bb09-e45cc23eb9f2
DOI: 10.21203/rs.3.rs-2835637/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Risk Assessment of Degenerative Eye Disease (GRADE): Design of a prospective assessment of polygenic risk scores to predict diagnosis of glaucoma and age-related macular degeneration.DOI 10.21203/rs.3.rs-2835637/v1Read

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestriesSemantic proximity Read

Polygenic Risk Scores Driving Clinical Change in Glaucoma.Semantic proximity Read

Polygenic risk scores for glaucoma: Impact on diagnosis and disease course.Semantic proximity Read

Risk Stratification and Clinical Utility of Polygenic Risk Scores in OphthalmologySemantic proximity Read

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.Semantic proximity Read

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across AncestriesSemantic proximity Read

Recall by polygenic risk score in two biobanks supports a genomic approach for glaucoma detectionSemantic proximity Read

The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.Semantic proximity Read

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.Semantic proximity Read

The Role of Polygenic Risk Scores in Glaucoma Management.Semantic proximity Read

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.Semantic proximity Read

Diversity in Polygenic Risk of Primary Open-Angle Glaucoma.Semantic proximity Read