Article
Machine Learning Reveals the Diversity of Human 3D Chromatin Contact Patterns.
Molecular biology and evolution - 4 Oct 2024
Gilbertson Erin N, Brand Colin M, McArthur Evonne, Rinker David C, Kuang Shuzhen, Pollard Katherine S, Capra John A
Abstract excerpt
Understanding variation in chromatin contact patterns across diverse humans is critical for interpreting noncoding variants and their effects on gene expression and phenotypes. However, experimental determination of chromatin contact patterns across large samples is prohibitively expensive. To overcome this challenge, we develop and validate a machine learning method to quantify the variation in 3D chromatin...
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