Article

Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation

2025-03-17

Abstract excerpt

The sequence-driven organising principles of the 3D genome are crucial for interpreting the core effects of genomic variation and for understanding the evolution of genome organisation and function. We investigated these by isolating and analysing cell-type-persistent contacts, heavily dependent on the similarly cell-type-persistent genomic sequence. We stratified long-range contacts from a diverse group of human...

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Literature Corpus work: 9444aef5-e09a-5749-958e-827147afdd38
DOI: 10.1101/2025.03.16.643527

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