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Article

Common DNA sequence variation influences 3-dimensional conformation of the human genome.

Genome biology - 28 Nov 2019

Gorkin David U, Qiu Yunjiang, Hu Ming, Fletez-Brant Kipper, Liu Tristin, Schmitt Anthony D, Noor Amina, Chiou Joshua, Gaulton Kyle J, Sebat Jonathan, Li Yun, Hansen Kasper D, Ren Bing

Abstract excerpt

BACKGROUND: The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known...

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Identifiers

PMID: 31779666
DOI: 10.1186/s13059-019-1855-4
PMCID: PMC6883528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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