Back to search

Article

Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence

2022-02-08

Abstract excerpt

Changes in gene regulation were a major driver of the divergence of archaic hominins (AHs)—Neanderthals and Denisovans—and modern humans (MHs). The three-dimensional (3D) folding of the genome is critical for regulating gene expression; however, its role in recent human evolution has not been explored because the degradation of ancient samples does not permit experimental determination of AH 3D genome folding. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fa73a988-3bc2-51b6-a127-cbd7869c964e
DOI
10.1101/2022.02.07.479462
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergenceDOI 10.1101/2022.02.07.479462
Machine learning reveals the diversity of human 3D chromatin contact patternsSemantic proximity
Machine Learning Reveals the Diversity of Human 3D Chromatin Contact Patterns.Semantic proximity
Predicting Archaic Hominin Phenotypes from Genomic Data.Semantic proximity
A global map for introgressed structural variation and selection in humansSemantic proximity
The genomic health of ancient homininsSemantic proximity
A high-coverage genome from a 200,000-year-old DenisovanSemantic proximity
Population Structure, Stratification, and Introgression of Human Structural Variation.Semantic proximity
Three-dimensional genome re-wiring in loci with Human Accelerated RegionsSemantic proximity
Deciphering complete archaic introgression sequences in modern human genomesSemantic proximity
A meta-analysis of ancient and present-day Central Eurasian genome data to revise archaic hominin ancestrySemantic proximity
A Refined Analysis of Neanderthal-Introgressed Sequences in Modern Humans with a Complete Reference GenomeSemantic proximity
The genomic landscape of Neanderthal ancestry in present-day humans.Semantic proximity
Select a neighboring publication to make it the new centre.