Article

Evaluating the contribution of genome 3D folding to variation in human height using machine learning

2025-09-15

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, yet the majority lie in noncoding regions, making it difficult to determine their functional impact. Alterations to the three-dimensional (3D) spatial interactions among gene regulatory elements are increasingly recognized as a mechanism by which genetic variants influence gene expression. However, experime...

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Literature Corpus work: 7768ff33-c705-5760-9e9d-dbe8fa72af28
DOI: 10.1101/2025.09.09.675195

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