Article

The 3D spatial constraint on 6.1 million amino acid sites in the human proteome

2021-09-16

Abstract excerpt

Quantification of the tolerance of protein-coding sites to genetic variation within human populations has become a cornerstone of the prediction of the function of genomic variants. We hypothesize that the constraint on missense variation at individual amino acid sites is largely shaped by direct 3D interactions with neighboring sites. To quantify the constraint on protein-coding genetic variation in 3D spatial ne...

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Literature Corpus work: 251d7ad9-0205-58dd-bfe8-24fe1afe1237
DOI: 10.1101/2021.09.15.460390

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