Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.

Immunity - 12 Nov 2024

Ross James L, Puigdelloses-Vallcorba Montserrat, Piñero Gonzalo, Soni Nishant, Thomason Wes, DeSisto John, Angione Angelo, Tsankova Nadejda M, Castro Maria G, Schniederjan Matthew, Wadhwani Nitin R, Raju G Praveen, Morgenstern Peter, Becher Oren J, Green Adam L, Tsankov Alexander M, Hambardzumyan Dolores

Abstract excerpt

Pediatric high-grade gliomas (pHGGs), including hemispheric pHGGs and diffuse midline gliomas (DMGs), harbor mutually exclusive tumor location-specific histone mutations. Using immunocompetent de novo mouse models of pHGGs, we demonstrated that myeloid cells were the predominant infiltrating non-neoplastic cell population. Single-cell RNA sequencing (scRNA-seq), flow cytometry, and immunohistochemistry...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Histones

Share to Macrophages

Share to Microglia

Share to Myeloid Cells

Share to Receptors, CCR5

Source

Open in PubMed Open full text

Identifiers

PMID: 39395421
DOI: 10.1016/j.immuni.2024.09.007
PMCID: PMC11578068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.PMID 39395421Read ↗

Histone H3K27M variants determine myeloid subset dependencies and immune reprogramming in diffuse midline glioma.Semantic proximity Read ↗

New insights into the Immune TME of adult-type diffuse gliomas.Semantic proximity Read ↗

Cancer-myeloid cell invasive program in pediatric-type diffuse high-grade gliomaSemantic proximity Read ↗

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressureSemantic proximity Read ↗

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophagesSemantic proximity Read ↗

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.Semantic proximity Read ↗

Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma.Semantic proximity Read ↗

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in GliomaSemantic proximity Read ↗

The genomic and transcriptional landscape of the spinal cord H3K27-altered diffuse midline glioma suggests the potential therapeutic strategySemantic proximity Read ↗

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilitiesSemantic proximity Read ↗

Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function.Semantic proximity Read ↗

Navigating the mutation maze: An oncogenic driver's guide to macrophage reprogramming.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.