Article
Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function.
Nature communications - 5 Sept 2024
Andrade Augusto Faria, Annett Alva, Karimi Elham, Topouza Danai Georgia, Rezanejad Morteza, Liu Yitong, McNicholas Michael, Gonzalez Santiago Eduardo G, Llivichuzhca-Loja Dhana, Gehlhaar Arne, Jessa Selin, De Cola Antonella, Chandarana Bhavyaa, Russo Caterina, Faury Damien, Danieau Geoffroy, Puligandla Evan, Wei Yuhong, Zeinieh Michele, Wu Qing, Hebert Steven, Juretic Nikoleta, Nakada Emily M, Krug Brian, Larouche Valerie, Weil Alexander G, Dudley Roy W R, Karamchandani Jason, Agnihotri Sameer, Quail Daniela F, Ellezam Benjamin, Konnikova Liza, Walsh Logan A, Pathania Manav, Kleinman Claudia L, Jabado Nada
Abstract excerpt
Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their tumor microenvironment (TME), particularly the immune infiltrate. Here, we characterize the immune TME of H3.3K27M and G34R/V-mutant gliomas, and multiple H3.3K27M mouse models, using...
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