Article
New insights into the Immune TME of adult-type diffuse gliomas.
Current opinion in neurology - 1 Dec 2022
Richard Quentin, Laurenge Alice, Mallat Michel, Sanson Marc, Castro-Vega Luis Jaime
Abstract excerpt
PURPOSE OF REVIEW: Adult-type diffuse gliomas are highly heterogeneous tumors. Bulk transcriptome analyses suggested that the composition of the tumor microenvironment (TME) corresponds to genetic and clinical features. In this review, we highlight novel findings on the intratumoral heterogeneity of IDH-wildtype and IDH-mutant gliomas characterized at single-cell resolution, and emphasize the mechanisms shaping...
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