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Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure

1 May 2025

Abstract excerpt

Pediatric high-grade gliomas (pHGGs) are among the most lethal childhood tumors. While therapeutic approaches were largely adapted from adult treatment regime, significant biological differences between pediatric and adult gliomas exist, which influence the immune microenvironment and may contribute to the limited response to current pHGG treatment strategies. We provide a comprehensive transcriptomic analysis of...

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PMID: 40315846
DOI: 10.1016/j.xcrm.2025.102095

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