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Article

Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma.

Neuro-oncology - 4 Mar 2024

DeSisto John, Donson Andrew M, Griesinger Andrea M, Fu Rui, Riemondy Kent, Mulcahy Levy Jean, Siegenthaler Julie A, Foreman Nicholas K, Vibhakar Rajeev, Green Adam L

Abstract excerpt

BACKGROUND: Pediatric high-grade gliomas (PHGG) are aggressive brain tumors with 5-year survival rates ranging from <2% to 20% depending upon subtype. PHGG presents differently from patient to patient and is intratumorally heterogeneous, posing challenges in designing therapies. We hypothesized that heterogeneity occurs because PHGG comprises multiple distinct tumor and immune cell types in varying proportions,...

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Identifiers

PMID: 37934854
DOI: 10.1093/neuonc/noad207
PMCID: PMC10912009

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