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Article

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.

Nature communications - 19 Feb 2021

Ochocka Natalia, Segit Pawel, Walentynowicz Kacper Adam, Wojnicki Kamil, Cyranowski Salwador, Swatler Julian, Mieczkowski Jakub, Kaminska Bozena

Abstract excerpt

Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that show prevalence in men. Cell heterogeneity and functional phenotypes of myeloid subpopulations in gliomas remain elusive. Here we show single-cell RNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33608526
DOI: 10.1038/s41467-021-21407-w
PMCID: PMC7895824

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