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Article

Navigating the mutation maze: An oncogenic driver's guide to macrophage reprogramming.

Immunity - 12 Nov 2024

Li Ziyi, Sharma Ankur

Abstract excerpt

The mechanisms by which oncogenic mutations and anatomical locations work together to influence the immune environment within tumors are not well understood. In this issue of Immunity, Ross et al. show that H3.3K27M diffuse midline gliomas (DMGs) are enriched with disease-associated myeloid cells (DAMs). Myeloid-targeted strategies reprogram DAMs to a homeostatic state, reduce myeloid infiltration into tumors,...

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PMID: 39536713
DOI: 10.1016/j.immuni.2024.10.007

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