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Article

Histone H3K27M variants determine myeloid subset dependencies and immune reprogramming in diffuse midline glioma.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2026

Puigdelloses Vallcorba Montserrat, Rawat Kavita, Soni Nishant, DiMauro Angela, Chu Jacqueline D, Thomason Wes, Furtado Glaucia C, Strahl Maya, Wu Junyan, Joshi Tanvi, Angione Angelo, Piñero Gonzalo, Becher Oren J, Ross James L, Tsankov Alexander M, Lira Sergio A, Hambardzumyan Dolores

Abstract excerpt

Diffuse midline gliomas (DMGs) are highly aggressive, WHO grade 4 glial tumors that arise in midline central nervous system structures and are defined by K27M mutations in histone H3 genes. These K27M mutations shape intratumoral myeloid cell composition in DMG. In H3.1K27M DMGs, genetic ablation of monocyte recruitment reshapes the tumor microenvironment (TME) by reducing monocyte-derived macrophages (MDMs) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42594274
DOI: 10.1073/pnas.2537768123
PMCID: PMC13486528

Genes

CCR1
CCR2
CCR3
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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