Article

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilities

2025-03-19

Abstract excerpt

<h4>Background</h4> Pediatric-type diffuse high-grade gliomas (pHGG) are a leading cause of pediatric cancer-related mortality. Although immunotherapy offers a promising treatment avenue, clinical responses in pHGG patients remain limited. A detailed understanding of the tumor immune microenvironment (TIME) is essential for advancing immunotherapeutic strategies. <h4>Methods</h4> We performed single-cell spatial...

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Literature Corpus work: 703c0d89-e289-5001-8ede-44cfb15f8d56
DOI: 10.1101/2025.03.18.643953

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Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilitiesDOI 10.1101/2025.03.18.643953Read

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