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Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action

16 Jul 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Screening large molecule libraries against pathogenic bacteria is often challenged by a low hit rate due to limited uptake, underrepresentation of antibiotic structural motifs, and assays that do not resemble the infection conditions. To address these limitations, we present a screen of a focused library of alkyl guanidinium compounds, a structural motif...

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Share to Antibiotic Resistance in Bacteria
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PMID: 39211621
DOI: 10.1021/jacsau.4c00449

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