Article

Forgotten Natural Products: Semisynthetic Development of Blasticidin S As an Antibiotic Lead

2024-02-23

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Forgotten natural products offer value as antimicrobial scaffolds, providing diverse mechanisms of action that complement existing antibiotic classes. This study focuses on the derivatization of the cytotoxin blasticidin S, seeking to leverage its unique ribosome inhibition mechanism. Despite its complex zwitterionic properties, a selective protection and amidatio...

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Literature Corpus work: 74a9410c-d56a-59cb-a75a-3057c8c2a1ee
DOI: 10.1021/acsmedchemlett.3c00527

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