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A strategy to re-sensitise drug-resistant Gram-positive bacteria to oxazolidinone-class antibiotics

1 Sept 2025

Abstract excerpt

BACKGROUND: Multidrug-resistant bacterial infections have high mortality rates and few treatment options. Synergistic combinations may improve clinical outcome but traditional strategies often damage healthy microbiome. Oxazolidinone-class antibiotics are typical last-resort drugs for treating drug-resistant bacterial infections but are becoming less effective due to resistance development. METHODS: After...

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PMID: 40912150
DOI: 10.1016/j.ebiom.2025.105914

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