Article

Structure-Uptake Relationship Studies of Oxazolidinones in Gram-negative ESKAPE Pathogens

2022-06-27

Abstract excerpt

To date, little is known about applicability and/or generality of molecular features and how they impact small molecule permeation into Gram-negative bacteria. Identifying motifs or structural trends that correlate with broad and/or species-specific permeation would enable the rational design of new antibacterials. The clinical success of linezolid for treating Gram-positive infections paired with the high conserv...

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Literature Corpus work: 2183244b-5085-5b20-b762-4bec778b94ab
DOI: 10.1101/2022.06.27.497815

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