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Thwarting resistance: MgrA inhibition with methylophiopogonanone a unveils a new battlefront against S. aureus

27 Feb 2024

Abstract excerpt

Limitations in the clinical treatment of Staphylococcus aureus (S. aureus) infections have arisen due to the advent of antibiotic-resistant strains. Given the immense potential of therapeutic strategies targeting bacterial virulence, the role of MgrA as a pivotal virulence determinant in S. aureus-orchestrating resistance, adherence, and hundreds of virulence targets-becomes indispensable. In this investigation,...

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Share to Antimicrobial Peptides and Activities
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PMID: 38413623
DOI: 10.1038/s41522-024-00485-w

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